Why take the ApoE test now?

In short, testing for the presence of the APOE-4 variant is the best way to understand your risk of developing Alzheimer’s.  In addition, testing for APOE and interpreting the results is the first step to allow your doctor to create a tailored program for you to help prevent the onset of Alzheimer’s disease if you already have it.

The APOE test will reveal not just whether you have the APOE-4 gene that has been proven to carry an increased risk of developing Alzheimer’s, but if risk is identified, further testing will show which factors must be corrected to prevent symptoms of Alzheimer’s. A healthy diet and lifestyle are key to protect the brain not only against the ravages of aging but also cardiovascular disease, autoimmune illnesses, and cognitive disorders like Alzheimer’s disease.

The APOE test is quick and easy to do at home, and the information is strictly protected by medical privacy laws.  Only you and your doctor will know what the tests reveal.

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How does ApoE relate to Alzheimer’s?

Although the precise cause and many potential contributors to Alzheimer’s disease are still being researched by scientists, it has been conclusively proven that individuals with the APEO-4 gene are far more likely to develop the disease. Individuals inherit zero, one, or two copies of the APOE-4 allele from their parents, leading to an increased risk of adult-onset Alzheimer’s in those with APOE-4.

According to the latest research, the APOE-4 protein triggers amyloid precursor protein (APP) to be cleaved into four chemical messengers that cause a build-up of amyloid plaques in the brain and synapse loss, principal characteristics of individuals with Alzheimer’s. In addition, the presence of the APOE-4 gene is also associated with increased rates of cardiovascular disease and inflammatory disorders.

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One of the forms of ApoE (ApoE4) increases a person’s risk of developing Alzheimer’s and other diseases.

While ApoE4 has the strongest impact on Alzheimer’s, the other two forms (APOE-e2 and APOE-e3) seem to protect against the disease. While people who inherit the ApoE4 form of the gene are at increased risk for the disease, they will not necessarily develop it. Risk genes increase the likelihood of developing a disease, but do not guarantee it will happen. Researchers have found several genes that increase the risk of Alzheimer’s. APOE-e4 is the first risk gene identified, and remains the gene with strongest impact on risk.

  • Alzheimer’s disease currently affects more that 5 million Americans.